L5793
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L5793
Sigma
Leupeptin hemisulfate salt
BioUltra, microbial, ≥98% (HPLC)
| Synonym: | Acetyl-Leu-Leu-Arg-al, N-Acetyl- |
| CAS Number: | 103476-89-7 |
| Linear Formula: | C20H38N6O4 · 1/2H2SO4 |
| Molecular Weight: | 475.59 |
| MDL number: | MFCD00037012 |
| PubChem Substance ID: | 24896420 |
Description
| Analysis Note | Leupeptin gives multiple peaks on HPLC due to equilibria among three forms in solution. Purity determined using three main peaks. Majority of contaminating peptide is racemized leupeptin. |
| Biochem/physiol Actions | Inhibitor of serine and cysteine proteases. Inhibits plasmin, trypsin, papain and cathepsin B. No inhibition found with pepsin, cathepsins A and D, thrombin, or α-chymotrypsin. Effective concentration 10-100 μM. |
Properties
| biological source | microbial |
| grade | BioUltra |
| assay | ≥98% (HPLC) |
| storage temp. | −20°C |
Safety
| Personal Protective Equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
| Safety Statements | 22-24/25 |
| WGK Germany | 3 |
References
| reference | Aoyagi, T., Inhibitor of trypsin, plasmin, papain and cathepsin B. J. Antibiot. 22, 283, (1969) |
| Saino, T., et al. Chem. Pharm. Bull. 30, 2319, (1982) | |
| Deutscher, M.P., Maintaining protein stability. Meth. Enzymol. 182, 83-89, (1990) | |
| Jazwinski, S.M., Preparation of extracts from yeast. Meth. Enzymol. 182, 154-174, (1990) | |
| , Beynon, R.J. and Bond, ed. Proteolytic Enzymes: A Practical Approach, (1989), 244-245 |
